Index

Handout for the Department Meeting 19910620

Amyotrophic Lateral Screlosis
Why endemic in 4 foci of Western Pacific?

1) About ALS...

¶ First Report: Charcot, J.M. and Joffroy, A. (1869) Deux cas d'atrophie musculaire progressive avec lésions de la substance grise et des faisceaux antérolatéraux de la moelle épiniére. Archives de Pathologie Normale et Pathologique 2: 354-367, 629-649, 744-760.

¶ Charcot, J.M. (1865) Gazette hebdomadaire

¶ Otomo, E. ed. (1986) Clinics of Neurology Vol. 4: Diseases and Treatment B, pp.61

2) Guam (U.S.A.; Chammoros)

¶ Kurland, L.T. and Mulder, D.W. (1954) Epidemiologic investigations of amyotrophic lateral sclerosis. 1. Preliminary report on geographic distribution, with special reference to the Mariana Islands, including clinical and pathological observations. Neurology 4: 355-378, 438-448.

¶ Garruto, R.M., Swyt, C., Fiori, C.E., Yanagihara, R. and Gajdusek D.C. (1985) Intraneuronal deposition of calcium and aluminum in amyotrophic lateral sclerosis. Lancet, 2:1353.

¶ Garruto, R.M., Swyt, C., Yanagihara, R., Fiori, C.E. and Gajdusek D.C. (1986) Intraneuronal co-localization of silicon with calcium and aluminum in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. New England Journal of Medicine, 315: 711-712.

¶ Garruto, R.M., Yanagihara, R. and Gajdusek, D.C. (1985) Disappearance of high-incidence amyotrophic lateral sclerosis and parkinsonism-dementia on Guam. Neurology, 35: 193-198.

3) Kii Peninsula (Japan; Kozagawa and Hobara people)

¶ Yase, Y. (1972) The pathogenesis of amyotrophic lateral screlosis. Lancet, 2: 292-296.

¶ Uebayashi, Y. (1980) Epidemiological investigation of motor neuron disease in the Kii Peninsula, Japan, and on Guam - the significance of long survival cases -. Wakayama Medical Reports, 23: 13-27.

4) Bade and Obaa Kechamatans (West New Guinea; Auyu and Jakai people)

¶ Gajdusek, D.C. and Salazar, A.M. (1982) Amyotrophic lateral sclerosis and parkinsonian syndromes in high incidence among the Auyu and Jakai people in West New Guinea. Neurology, 32: 107-126.

5) Northern Australia (Australia; Aboriginal people)

¶ Cawte, J., Kilburn, C. and Florence, M. (1989) Motor neurone disease of the Western Pacific: Do the foci extend to Australia? Neurotoxicology, 10: 263-270.

6) Hypothesis

¶ Garruto, R.M., Yanagihara, R. and Gajdusek, D.C. (1988) Cycads and amyotrophic lateral sclerosis / parkinsonism-dementia. Lancet, (2): 1079.

¶ Garruto, R.M., Shankar, S.K., Yanagihara, R., Salazar, A.M., Amyx, H.L. and Gajdusek, D.C. (1989) Low-calcium, high-aluminum diet-induced motor neuron pathology in cynomolgus monkeys. Acta Neuropathologica, 78: 210-219.

¶ Gajdusek, D.C. (1985) Hypothesis: interference with axonal transport of neurofilament as a common pathogenic mechanism in certain diseases of the central nervous system. New England Journal of Medicine, 312: 714-719.